{"id":12070,"date":"2022-07-06T18:14:29","date_gmt":"2022-07-06T21:14:29","guid":{"rendered":"https:\/\/jasminealimentos.com\/pro\/?p=12070"},"modified":"2022-07-06T18:29:07","modified_gmt":"2022-07-06T21:29:07","slug":"flavonoides-com-poder-prebiotico-entenda-esse-novo-conceito-de-flavobioticos","status":"publish","type":"post","link":"https:\/\/jasminealimentos.com\/pro\/flavonoides-com-poder-prebiotico-entenda-esse-novo-conceito-de-flavobioticos\/","title":{"rendered":"Flavon\u00f3ides com poder prebi\u00f3tico: entenda esse novo conceito de flavobi\u00f3ticos"},"content":{"rendered":"\t\t
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Polifen\u00f3is s\u00e3o metab\u00f3litos secund\u00e1rios de origem vegetal encontrados em alimentos como hortali\u00e7as, frutas, cereais, ch\u00e1, caf\u00e9, cacau e vinho; os quais desempenham papel importante nos sistemas de defesa da planta, fornecendo prote\u00e7\u00e3o contra, por exemplo, pat\u00f3genos, insetos e radia\u00e7\u00e3o UV (STEVENS et al., 2019; SINGH et al., 2019).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Os principais grupos de polifen\u00f3is s\u00e3o: \u00e1cidos fen\u00f3licos, flavon\u00f3ides, taninos, estilbenos e diferuloilmetanos. Os flavonoides \u00e9 o maior e mais estudado grupo, estando presente em diversos alimentos e com participa\u00e7\u00e3o importante na sa\u00fade humana (STEVENS et al., 2019; SINGH et al., 2019).\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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O EIXO DO MICROBIOMA COM A SAUDABILIDADE <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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A coloniza\u00e7\u00e3o microbiana no trato gastrointestinal come\u00e7a imediatamente ap\u00f3s o nascimento e \u00e9 feita por bact\u00e9rias, archaea, v\u00edrus, eucariotos e outras esp\u00e9cies de microrganismos (RODR\u00cdGUEZ-DAZA et al., 2021; KASPRZAK-DROZD et al. 2021).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Sabe-se que existe uma rela\u00e7\u00e3o simbi\u00f3tica entre o microbioma intestinal e o hospedeiro, e que essa associa\u00e7\u00e3o \u00e9 complexa e multidimensional, pois afeta v\u00e1rios eixos do organismo, como:
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- Intestino-pulm\u00e3o;\n
- Intestino-c\u00e9rebro;\n
- Intestino-pele;\n
- Intestino-m\u00fasculo;\n
- Intestino-tecido adiposo.\n
(RODR\u00cdGUEZ-DAZA et al., 2021).\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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M\u00faltiplos fatores podem interferir nesse delicado equil\u00edbrio, incluindo gen\u00e9tica, idade, medicamentos e fatores ambientais; principalmente a dieta, a qual tem participa\u00e7\u00e3o significativa na modula\u00e7\u00e3o da microbiota intestinal (RODR\u00cdGUEZ-DAZA et al., 2021; KASPRZAK-DROZD et al. 2021).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A estreita conex\u00e3o entre o microbioma e as respostas metab\u00f3licas end\u00f3genas do hospedeiro est\u00e1 relacionada com o desenvolvimento e a evolu\u00e7\u00e3o de doen\u00e7as cardiometab\u00f3licas, inflama\u00e7\u00e3o intestinal, altera\u00e7\u00f5es cognitivas e dist\u00farbios neuropsicol\u00f3gicos (RODR\u00cdGUEZ-DAZA et al., 2021).<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Os flavon\u00f3ides como agentes modulares da microbiota intestinal <\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Os polifen\u00f3is possuem a\u00e7\u00e3o antioxidante e anti-inflamat\u00f3ria, sendo ben\u00e9ficos \u00e0 sa\u00fade, devido a sua a\u00e7\u00e3o terap\u00eautica na preven\u00e7\u00e3o de doen\u00e7as cr\u00f4nicas relacionadas ao estresse oxidativo (RAVIND et al., 2021; KASPRZAK-DROZD et al. 2021).<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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De acordo com, Rodr\u00edguez-Daza et al (2021) os polifen\u00f3is agem na microbiota intestinal por meio de mecanismos antimicrobianos e estimulantes do crescimento tendo, portanto, potencial a\u00e7\u00e3o prebi\u00f3tica, podendo:
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- Prevenir doen\u00e7as metab\u00f3licas e inflamat\u00f3rias;\n
- Aumentar a s\u00edntese de muco intestinal do hospedeiro;\n
- Induzir a secre\u00e7\u00e3o de pept\u00eddeos antimicrobianos no intestino;\n
- Modular os \u00e1cidos biliares hep\u00e1ticos e a secre\u00e7\u00e3o de imunoglobulinas intestinais.\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Os polifen\u00f3is s\u00e3o capazes de interagir com prote\u00ednas bacterianas e inibir a s\u00edntese de \u00e1cidos nucleicos dessas bact\u00e9rias, alterando fun\u00e7\u00e3o, fluidez da membrana celular; a integridade e a s\u00edntese da parede celular; afetando o metabolismo celular e prevenindo a forma\u00e7\u00e3o de biofilme. Da mesma forma, esses compostos podem inibir o quorum sensing<\/i> e quelar metais essenciais como ferro, cobre e zinco; os quais s\u00e3o essenciais para o metabolismo bacteriano (RODR\u00cdGUEZ-DAZA et al., 2021).

\n\nAl\u00e9m da inibi\u00e7\u00e3o do crescimento de bact\u00e9rias patog\u00eanicas, esses polifen\u00f3is tamb\u00e9m s\u00e3o capazes de proteger o epit\u00e9lio intestinal e restaurar a homeostase da microbiota alterada em diversas condi\u00e7\u00f5es cl\u00ednicas. Suas a\u00e7\u00f5es antimicrobianas influenciam m\u00faltiplas respostas gen\u00e9ticas, como varia\u00e7\u00e3o da resist\u00eancia a antibi\u00f3ticos, altera\u00e7\u00f5es metab\u00f3licas, arquitetura da superf\u00edcie celular e vias envolvidas no estresse oxidativo (RODR\u00cdGUEZ-DAZA et al., 2021).<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tA Jasmine possui uma s\u00e9rie de alimentos que cont\u00e9m polifen\u00f3is, como: Red Berries, Cranberries e Goji Berry. Al\u00e9m disso, a aveia \u00e9 um alimento funcional com compostos bioativos, como avenantramidas, que auxiliam na modula\u00e7\u00e3o intestinal.<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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REFER\u00caNCIAS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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STEVENS, Yala; et al. The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health. Nutrients<\/strong>, [S.L.], v. 11, n. 7, p. 1464, 27 jun. 2019. Dispon\u00edvel em: https:\/\/www.mdpi.com\/2072-6643\/11\/7\/1464\/htm. Acesso em: 16 mai. 2022.<\/p>

\u00a0<\/p>

SINGH, Amit Kumar; et al. Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency. Nutrients<\/strong>, [S.L.], v. 11, n. 9, p. 2216, 13 set. 2019. Dispon\u00edvel em: https:\/\/www.mdpi.com\/2072-6643\/11\/9\/2216\/htm. Acesso em: 16 mai. 2022.<\/p>

\u00a0<\/p>

RODR\u00cdGUEZ-DAZA, M.C.; et al. Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further. Front Nutr<\/strong>. 28 jun. 2021. Dispon\u00edvel em: https:\/\/pubmed.ncbi.nlm.nih.gov\/34268328\/. Acesso em: 16 mai. 2022.<\/p>

\u00a0<\/p>

KASPRZAK-DROZD, Kamila; et al. Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome. International Journal Of Molecular Sciences<\/strong>, [S.L.], v. 22, n. 7, p. 3715, 2 abr. 2021. Dispon\u00edvel em: https:\/\/pubmed.ncbi.nlm.nih.gov\/33918284\/. Acesso em: 16 mai. 2022.<\/p>

\u00a0<\/p>

RAVIND, S. Mithul; et al. Role of dietary polyphenols on gut microbiota, their metabolites and health benefits.\u00a0Food Research International<\/strong>, [S.L.], v. 142, p. 110189, abr. 2021.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Polifen\u00f3is s\u00e3o metab\u00f3litos secund\u00e1rios de origem vegetal encontrados em alimentos como hortali\u00e7as, frutas, cereais, ch\u00e1, caf\u00e9, cacau e vinho; os quais desempenham papel importante nos sistemas de defesa da planta, fornecendo prote\u00e7\u00e3o contra, por exemplo, pat\u00f3genos, insetos e radia\u00e7\u00e3o UV (STEVENS et al., 2019; SINGH et al., 2019). Os principais grupos de polifen\u00f3is s\u00e3o: \u00e1cidos […]<\/p>\n","protected":false},"author":2,"featured_media":12072,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[172,176,173,174,175],"tags":[217,218],"class_list":["post-12070","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nutricao-clinica","category-nutricao-comportamental","category-nutricao-esportiva","category-nutricao-estetica","category-nutricao-materno-infantil","tag-flavobioticos-microbiota-intestinal-inflamacao-intestinal-saude-gastrointestinal","tag-microbioma-prebioticos-polifenois-nutricao-funcional-probioticos-dieta-anti-inflamatoria-dieta-antioxidante"],"yoast_head":"\nFlavon\u00f3ides com poder prebi\u00f3tico: entenda esse novo conceito de flavobi\u00f3ticos - Portal Jasmine Pro<\/title>\n<meta name=\"description\" content=\"O envelhecimento \u00e9 decorrente de m\u00faltiplos fatores. 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